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Literature summary extracted from

  • Sun, M.; Zhao, Y.; Gu, Y.; Xu, C.
    Inhibition of nNOS reduces ischemic cell death through down-regulating calpain and caspase-3 after experimental stroke (2009), Neurochem. Int., 54, 339-346.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.52 alpha-spectrin + H2O Rattus norvegicus
-
 ?
-
 ?
3.4.22.52 MAP2 + H2O Rattus norvegicus
-
 ?
-
 ?
3.4.22.56 additional information Rattus norvegicus caspase-3 is involved in the ischemic brain injury during experimental stroke. In vitro nitric oxide regulates calpain and caspase-3 activation, and in vivo neuronal nitric oxide synthase, calpain and caspase-3 participate in the ischemic brain injury, inhibition of the neuronal nitric oxide synthase by 7-nitroindazole leads to downregulation of caspase-3, mechanism, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.52 Rattus norvegicus
-
-
-
3.4.22.56 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.52 brain penumbra Rattus norvegicus
-
3.4.22.52 brain cortex
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 Rattus norvegicus
-
3.4.22.52 corpus striatum
-
 Rattus norvegicus
-
3.4.22.56 brain caspase-3 is increased in ischemic brain, in penumbra and core Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.52 alpha-spectrin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.22.52 casein + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.22.52 MAP2 + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.22.56 DEVD-7-amido-4-fluoromethylcoumarin + H2O
-
 Rattus norvegicus DEVD + 7-amino-4-fluoromethylcoumarin
-
 ?
3.4.22.56 additional information caspase-3 is involved in the ischemic brain injury during experimental stroke. In vitro nitric oxide regulates calpain and caspase-3 activation, and in vivo neuronal nitric oxide synthase, calpain and caspase-3 participate in the ischemic brain injury, inhibition of the neuronal nitric oxide synthase by 7-nitroindazole leads to downregulation of caspase-3, mechanism, overview Rattus norvegicus ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.52 mu-calpain
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 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.56 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.56 7.4
-
 assay at Rattus norvegicus

Expression

EC Number Organism Comment Expression
3.4.22.52 Rattus norvegicus treatment with 50 mg/kg 7-nitroindozale shows significant suppression of the activity of mu-calpain in brain cortex (penumbra), however, it has no significant effect on the mu-calpain activity in core (striatum and overlying cortex) down